| 24/07/2022 16:15 | OH Leuven | 1-1 | Zulte Waregem |
| - | 24' Jelle Vossen | ||
| Thomas Henry (pen) 42' | - | ||
| 31/07/2022 18:30 | Cercle Brugge | 1-1 | OH Leuven |
| - | 30' Thomas Henry | ||
| Waldo Rubio 73' | - | ||
| 8/08/2022 16:00 | OH Leuven | 1-1 | Charleroi |
| - | 8' Adem Zorgane | ||
| Thomas Henry 61' | - | ||
| 14/08/2022 20:45 | KRC Genk | 4-0 | OH Leuven |
| Theo Bongonda 3' | - | ||
| Paul Onuachu 59' | - | ||
| Junya Ito 77' | - | ||
| Kristian Thorstvedt 90+2' | - | ||
| 21/08/2022 18:30 | OH Leuven | 1-4 | Eupen |
| - | 32' Smail Prevljak | ||
| - | 39' Julien Ngoy | ||
| - | 56' Jocelyn N’dri | ||
| - | 80' Emmanuel Agbadou | ||
| Levan Shengelia 83' | - | ||
| 29/08/2022 16:00 | Antwerp | 2-2 | OH Leuven |
| Mathieu Maertens 38' | - | ||
| Michael Frey (pen) 45+2' | - | ||
| - | 55' Cenk Ozkacar | ||
| - | 76' Levan Shengelia | ||
| 12/09/2022 21:00 | OH Leuven | 2-1 | KV Kortrijk |
| Alexis De Sart 50' | - | ||
| - | 62' Faïz Selemani | ||
| Siebe Schrijvers 78' | - | ||
| 18/09/2022 18:30 | KV Mechelen | 2-0 | OH Leuven |
| Nikola Storm 8' | - | ||
| Kerim Mrabti 44' | - | ||
| 24/09/2022 20:45 | Club Brugge | 1-1 | OH Leuven |
| - | 42' Cenk Ozkacar | ||
| Clinton Mata 77' | - | ||
| 2/10/2022 20:45 | OH Leuven | 0-0 | Beerschot |
| 16/10/2022 20:45 | Standard | 2-2 | OH Leuven |
| Abdoul Fessal Tapsoba 39' | - | ||
| Denis Drăguş 50' | - | ||
| - | 90+6' Xavier Mercier | ||
| - | 90+9' Sory Kaba | ||
| 24/10/2022 21:00 | OH Leuven | 4-1 | STVV |
| Sory Kaba 60' | - | ||
| - | 63' Dimitri Lavalée | ||
| Siebe Schrijvers 67' | - | ||
| Sory Kaba (pen) 78' | - | ||
| Mathieu Maertens 82' | - | ||
| 27/10/2022 20:45 | Lierse Kempenzonen | 1-2 | OH Leuven |
| - | 63' Sory Kaba (pen) | ||
| Jordi Liongola 80' | - | ||
| - | 90+14' Sory Kaba | ||
| 31/10/2022 18:30 | Anderlecht | 2-2 | OH Leuven |
| - | 6' Sory Kaba | ||
| - | 15' Mathieu Maertens | ||
| Joshua Zirkzee 40' | - | ||
| Joshua Zirkzee 90+4' | - | ||
| 5/11/2022 20:45 | OH Leuven | 1-0 | KV Oostende |
| Xavier Mercier 65' | - | ||
| 20/11/2022 18:30 | OH Leuven | 1-3 | Seraing |
| - | 20' Georges Mikautadze | ||
| - | 71' Youssef Maziz | ||
| Mathieu Maertens 73' | - | ||
| - | 86' Gerald Kilota | ||
| 26/11/2022 20:45 | Union SG | 1-3 | OH Leuven |
| - | 13' Casper De Norre | ||
| - | 40' Mathieu Maertens | ||
| Kaoru Mitoma 51' | - | ||
| - | 67' Xavier Mercier | ||
| 1/12/2022 18:45 | Westerlo | 2-3 | OH Leuven |
| Christoffer Remmer 22' | - | ||
| - | 55' Casper De Norre | ||
| Jan Bernat 67' | - | ||
| - | 89' Siebe Schrijvers | ||
| - | 90+3' Mathieu Maertens | ||
| 4/12/2022 16:15 | OH Leuven | 0-1 | KAA Gent |
| - | 10' Tarik Tissoudali | ||
| 11/12/2022 16:15 | KV Kortrijk | 2-1 | OH Leuven |
| Trent Sainsbury 63' | - | ||
| - | 72' Jesse Tamunobaraboye Sekidika | ||
| Faïz Selemani 89' | - | ||
| 15/12/2022 21:00 | OH Leuven | 1-4 | Club Brugge |
| - | 26' Noa Lang | ||
| - | 67' Charles De Ketelaere | ||
| - | 71' Ruud Vormer | ||
| - | 75' Charles De Ketelaere | ||
| Mathieu Maertens 85' | - | ||
| 19/12/2022 21:00 | OH Leuven | 2-1 | Standard |
| Mathieu Maertens 15' | - | ||
| Mathieu Maertens 38' | - | ||
| - | 90+4' Collins Fai | ||
| 23/12/2022 21:00 | Club Brugge | 4-1 | OH Leuven |
| Charles De Ketelaere 40' | - | ||
| Eder Balanta 45+6' | - | ||
| - | 58' Xavier Mercier | ||
| - | 59' | ||
| Noa Lang 63' | - | ||
| Hans Vanaken 90+2' | - | ||
| 27/12/2022 18:45 | Charleroi | 0-3 | OH Leuven |
| - | 17' Casper De Norre | ||
| - | 54' Musa Al-Tamari | ||
| - | 74' Sory Kaba | ||
| 15/01/2022 16:15 | OH Leuven | 5-0 FF | KV Mechelen |
| 2'2-1 18:30:00 | Beerschot | 3-1 | OH Leuven |
| - | 8' Siebe Schrijvers | ||
| Paolo Mauricio Lemos Merladey 24' | - | ||
| Joren Dom 38' | - | ||
| Jan Van Den Bergh 90' | - | ||
| 26/01/2022 18:45 | Zulte Waregem | 1-1 | OH Leuven |
| - | 29' Sory Kaba | ||
| Jelle Vossen 40' | - | ||
| 5/02/2022 18:30 | KV Oostende | 1-3 | OH Leuven |
| - | 34' Levan Shengelia | ||
| - | 48' Sory Kaba | ||
| Maxime D'Arpino 56' | - | ||
| - | 85' Musa Al-Tamari | ||
| 9/02/2022 21:00 | OH Leuven | 2-1 | KRC Genk |
| Sory Kaba 1' | - | ||
| - | 19' Mujaid Sadick Aliu | ||
| Sory Kaba (pen) 90+3' | - | ||
| 1'2-2 18:30:00 | OH Leuven | 3-2 | Cercle Brugge |
| - | 32' Rabbi Matondo | ||
| Mathieu Maertens 40' | - | ||
| - | 43' Kévin Denkey | ||
| Sory Kaba 63' | - | ||
| Musa Al-Tamari 67' | - | ||
| 20/02/2022 21:00 | STVV | 2-0 | OH Leuven |
| Taichi Hara 19' | - | ||
| Daichi Hayashi 90+4' | - | ||
| 26/02/2022 20:45 | OH Leuven | 0-0 | Anderlecht |
| 6/03/2022 21:00 | Eupen | 3-1 | OH Leuven |
| Gary Magnée 11' | - | ||
| - | 31' Mathieu Maertens | ||
| Isaac Nuhu 49' | - | ||
| Smail Prevljak 71' | - | ||
| 1'1-3 20:45:00 | OH Leuven | 1-4 | Union SG |
| Siebe Schrijvers (pen) 11' | - | ||
| - | 27' Deniz Undav | ||
| - | 48' Deniz Undav | ||
| - | 58' Teddy Teuma | ||
| - | 62' Deniz Undav (pen) | ||
| 19/03/2022 18:30 | Seraing | 1-1 | OH Leuven |
| - | 47' Alexis De Sart | ||
| Youssef Maziz 86' | - | ||
| 2/04/2022 20:45 | OH Leuven | 0-1 | Antwerp |
| - | 39' Abdoulaye Seck | ||
| 10/04/2022 18:30 | KAA Gent | 5-0 | OH Leuven |
| Julien De Sart 42' | - | ||
| Tarik Tissoudali 48' | - | ||
| Andrew Hjulsager 86' | - | ||
| Tarik Tissoudali 89' | - | ||
| Tarik Tissoudali 90' | - | ||
