| 10/08/2021 19:00 | OH Leuven | 1-1 | Eupen |
| Sascha Kotysch 57' | |||
| 72' Isaac Nuhu | |||
| 15/08/2021 16:30 | KRC Genk | 1-1 | OH Leuven |
| Junya Ito 55' | |||
| - | 85' Thomas Henry | ||
| 22/08/2021 18:30 | OH Leuven | 1-3 | Charleroi |
| 6' Dorian Dessoleil | |||
| Xavier Mercier 34' | - | ||
| 49' Mamadou Fall | |||
| 80' Kaveh Rezaei | |||
| 29/08/2021 18:30 | Waasland-Beveren | 1-3 | OH Leuven |
| - | 30' Xavier Mercier | ||
| Joseph Efford 51' | - | ||
| - | 58' Sascha Kotysch | ||
| - | 90' Thomas Henry | ||
| 12/09/2021 18:30 | OH Leuven | 1-0 | Standard |
| Kamal Sowah 77' | - | ||
| 19/09/2021 16:15 | KV Oostende | 3-1 | OH Leuven |
| Junior Fashion Sakala 26' | - | ||
| Junior Fashion Sakala 50' | - | ||
| Makhtar Gueye 60' | - | ||
| - | 79' Mathieu Maertens | ||
| 26/09/2021 20:45 | KAA Gent | 2-3 | OH Leuven |
| - | 41' Kamal Sowah | ||
| - | 44' Mathieu Maertens | ||
| - | 48' Kamal Sowah | ||
| Niklas Dorsch (pen) 71' | - | ||
| Tim Kleindienst (pen) 74' | - | ||
| 3/10/2021 18:30 | OH Leuven | 2-1 | Zulte Waregem |
| Thomas Henry 19' | - | ||
| Kamal Sowah 63' | - | ||
| - | 70' Saido Berahino | ||
| 11/10/2021 16:00 | Knokke | 0-2 | OH Leuven |
| 18/10/2021 20:30 | Anderlecht | 2-2 | OH Leuven |
| Yari Verschaeren 38' | - | ||
| Percy Tau 45' | - | ||
| - | 53' Frédéric Duplus | ||
| - | 84' Mathieu Maertens | ||
| 24/10/2021 20:45 | OH Leuven | 2-1 | Club Brugge |
| Thomas Henry (pen) 21' | - | ||
| - | 45' Noa Lang (pen) | ||
| Xavier Mercier 57' | - | ||
| 31/10/2021 16:15 | Beerschot | 4-2 | OH Leuven |
| - | 16' Xavier Mercier | ||
| Tarik Tissoudali 21' | - | ||
| Musashi Suzuki 25' | - | ||
| Ryan Sanusi 62' | - | ||
| Raphael Holzhauser 65' | - | ||
| - | 82' Thomas Henry (pen) | ||
| 23/11/2021 20:45 | OH Leuven | 2-2 | STVV |
| - | 27' Duckens Nazon | ||
| Thomas Henry (pen) 45' | - | ||
| Josh Eppiah 73' | - | ||
| - | 84' Duckens Nazon | ||
| 30/11/2021 20:45 | Antwerp | 3-2 | OH Leuven |
| Dylan Batubinsika 5' | - | ||
| Dieumerci Mbokani 8' | - | ||
| - | 12' Thomas Henry (pen) | ||
| - | 17' Kamal Sowah | ||
| Martin Hongla 57' | - | ||
| 5/12/2021 18:30 | OH Leuven | 2-1 | Cercle Brugge |
| Kamal Sowah 10' | - | ||
| Thomas Henry 54' | - | ||
| - | 90' Ike Ugbo | ||
| 8/12/2021 17:00 | OH Leuven | 2-0 | Moeskroen |
| Pierre-Yves Ngawa 56' | - | ||
| Thomas Henry 84' | - | ||
| 12/12/2021 18:30 | KV Kortrijk | 0-3 | OH Leuven |
| - | 47' Thomas Henry | ||
| - | 64' Thomas Henry | ||
| - | 87' Thomas Henry | ||
| 15/12/2021 18:45 | Moeskroen | 2-2 | OH Leuven |
| - | 42' Thibault Vlietinck | ||
| - | 55' David Hubert (pen) | ||
| Nuno Da Costa 71' | - | ||
| Nuno Da Costa 77' | - | ||
| 20/12/2021 16:00 | OH Leuven | 1-2 | KV Mechelen |
| - | 27' Kerim Mrabti | ||
| - | 30' Joachim Van Damme | ||
| Thomas Henry 61' | - | ||
| 26/12/2021 18:30 | OH Leuven | 1-2 | KV Oostende |
| Kristiyan Malinov 35' | - | ||
| - | 59' Arthur Theate | ||
| - | 72' Pierre-Yves Ngawa | ||
| 10/01/2021 18:15 | OH Leuven | 1-0 | Anderlecht |
| Thomas Henry (pen) 87' | - | ||
| 17/01/2021 20:45 | STVV | 3-1 | OH Leuven |
| Yuma Suzuki 10' | - | ||
| - | 25' Thomas Henry | ||
| Ilombé Mboyo 39' | - | ||
| Yuma Suzuki 53' | - | ||
| 21/01/2021 18:45 | Zulte Waregem | 2-3 | OH Leuven |
| Panagiotis Armenakas 29' | - | ||
| Mathieu De Smet 42' | - | ||
| - | 44' Xavier Mercier | ||
| - | 75' Thomas Henry | ||
| - | 90+5' Xavier Mercier (pen) | ||
| 24/01/2021 20:45 | OH Leuven | 0-3 | KAA Gent |
| - | 6' Milad Mohammadi | ||
| - | 50' Sven Kums | ||
| - | 54' Osman Bukari | ||
| 27/01/2021 21:00 | Charleroi | 1-1 | OH Leuven |
| - | 12' Kamal Sowah | ||
| Dorian Dessoleil 61' | - | ||
| 30/01/2021 18:30 | OH Leuven | 0-1 | Beerschot |
| - | 74' Tarik Tissoudali | ||
| 3/02/2021 18:00 | OH Leuven | 2-3 | Cercle Brugge |
| - | 2' Dino Hotič (pen) | ||
| Mathieu Maertens 3' | - | ||
| - | 39' Jean Marcelin | ||
| - | 72' Jérémy Taravel (pen) | ||
| David Hubert 90' | - | ||
| 6/02/2021 20:45 | Standard | 1-1 | OH Leuven |
| - | 60' Thomas Henry | ||
| João Klauss 84' | - | ||
| 12/02/2021 20:45 | OH Leuven | 3-1 | KV Kortrijk |
| Thomas Henry 10' | - | ||
| Thomas Henry 20' | - | ||
| Kamal Sowah 40' | - | ||
| - | 52' Zinho Gano | ||
| 22/02/2021 20:45 | Club Brugge | 3-0 | OH Leuven |
| Ignace Van Der Brempt 8' | - | ||
| Ruud Vormer (pen) 39' | - | ||
| Clinton Mata 90+3' | - | ||
| 1/03/2021 20:45 | OH Leuven | 2-0 | Antwerp |
| Xavier Mercier 25' | - | ||
| Musa Al-Tamari 29' | - | ||
| 6/03/2021 16:15 | Eupen | 3-3 | OH Leuven |
| - | 27' Kristiyan Malinov | ||
| Jonathan Heris 29' | - | ||
| - | 36' Thomas Henry | ||
| Knowledge Musona (pen) 43' | - | ||
| - | 55' Xavier Mercier | ||
| Knowledge Musona 67' | - | ||
| 21/03/2021 16:00 | KV Mechelen | 2-2 | OH Leuven |
| Aster Vranckx 30' | - | ||
| - | 40' Casper De Norre | ||
| - | 70' Siebe Schrijvers | ||
| Ferdy Druijf (pen) 80' | - | ||
| 5/04/2021 13:30 | OH Leuven | 2-3 | KRC Genk |
| Thomas Henry ' | - | ||
| - | 7' Kristian Thorstvedt | ||
| Xavier Mercier 74' | - | ||
| - | 81' Theo Bongonda | ||
| - | 83' Paul Onuachu | ||
| Thomas Henry 90+2' | - | ||
| 10/04/2021 16:15 | Cercle Brugge | 3-0 | OH Leuven |
| Ike Ugbo 44' | - | ||
| Ike Ugbo 56' | - | ||
| Jérémy Taravel 73' | - | ||
| 18/04/2021 18:00 | OH Leuven | 1-2 | Waasland-Beveren |
| - | 30' Louis Verstraete | ||
| Siebe Schrijvers 47' | - | ||
| - | 67' Louis Verstraete | ||
